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MSDC-0602K is a second-generation thiazolidinedione designed to preferentially suppress the mitochondrial pyruvate carrier while minimizing direct binding to PPAR

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The CPT1A enzyme is essential for fatty acid oxidation, as it binds fatty acids to carnitine, which transports them to the mitochondria where they are used for energy generation

Chen Z, Gao Y, Huang X, Yao Y, Chen K, Zeng S, et al