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10.1016/j.ebiom.2018.03.029 125 Palanca-BallesterC.Rodriguez-CasanovaA.TorresS.Calabuig-FariasS.ExpositoF.SerranoD.et al (2021)

These studies revealed that tirzepatide is an imbalanced and biased dual GIP-R/GLP-1R co-agonist, which stimulates GIP receptors in a manner analogous to its parent peptide but favors cAMP generation over -arrestin recruitment at the GLP-1R

A synthetic peptide consisting of 83 amino acids, it mimics the action of the natural compound with certain changes, improving the stability and efficiency of the peptide