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While GLP-1 RAs offer promising therapeutic outcomes, clinicians must address potential challenges, including gastrointestinal side effects, contraindications (e.g., pregnancy, severe GI disorders), and risks associated with improper compounding practices (48)(540)

Another study indicated that irisin could attenuate inflammation induced by oxygen-glucose deprivation by inhibiting reactive oxygen species (ROS) and the NLRP3 inflammatory signaling pathway ( Irisin plays a significant role in macrophage polarization and its anti-inflammatory function

Glucagon receptor agonism directly promotes hepatic fat clearance, making mazdutide mechanistically suited for MASH/NASH-related metabolic goals beyond weight loss alone

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