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The 6-day half-life means drug levels remain relatively stable throughout the week, providing consistent appetite suppression and metabolic effects without daily dosing

Both drugs can have serious interactions with monoamine oxidase inhibitors (MAOIs), other antidepressants, some antipsychotics, and other CNS stimulants

These effects were compared to those of untreated controls that were also maintained on a high-fat diet.393 As a result, GLP-1RAs could mitigate the detrimental effects of hyperlipidemia-induced skeletal defects, leading to an improved prognosis in individuals with OA

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We considered both review and original research articles involving L