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Further, lipid peroxidation has been found to decrease the membrane's ability to uptake glucose as well as respond to varying levels of immune challenges[7]

GLP-1 receptor agonists modulate blood glucose levels in T2DM by affecting Faecalibacterium prausnitzii abundance in the intestine

On the other hand, the vasodilatory effects of GLP-1 RAs can also be mediated through amelioration of endothelial function, which in turn affects vascular smooth muscle tone through release of nitric oxide, endothelium-derived hyperpolarizing factor, and prostacyclins (Sandoo et al., 2010)