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Notably, in four different clinical trials, Wellbutrin was associated with less sexual dysfunction (and more sexual satisfaction) than experienced by participants taking sertraline (Zoloft) or fluoxetine (Prozac). One large 2016 systematic review and meta-analysis used data from 51 studies spanning 20 years to examine Wellbutrins effectiveness in treating depression. The findings support a therapeutic role for bupropion, either a sole treatment (or prescribed with another antidepressant), especially if there is concern about weight gain and sexual dysfunction side effects from other medications. If you are taking Wellbutrin it's crucial to follow your doctor's instructions precisely

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