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Modulating neuronal ferroptosis to intervene in the secondary injuries of TBI is increasingly becoming a focus of interest in the neuroscience community (Yan et al., 2021)

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Unwinding of helix VI disrupts the ionic lock interactions between R348 6.37b and E408 7.63b and destabilizes the hydrogen-bond interaction between H180 2.50b and E247 3.50b

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Furthermore, Y358 is locked in place by E383 and K436, an electrostatic pair conserved in OCTs and OATs 34 that is involved in the coordination and release of substrates within the pocket 29 (Supplementary Fig

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