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2016 Jan 5;315(1):90 )

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Revita is Fractyl Health's lead product candidate, designed to remodel the duodenal lining via a minimally invasive endoscopic procedure to restore healthy nutrient sensing and signalling disrupted by chronic metabolic diseases

Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness