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Several studies have shown that TGF-1 upregulates glutaminase 1 (GLS1), enhancing the conversion of glutamine to glutamate, a critical step for collagen biosynthesis [97,98,99]

Final remarks There is a promising horizon of new obesity pharmacotherapies on the way ( Figure 1 )

A 1-way ANOVA was used to analyze differences between 3 or more treatment groups using GraphPad Prism, version 4.0 (GraphPad Software)

Gut microbiota metabolites protect the intestines The gut microbiota shows an immense influence on host health, and any perturbation in the host-gut crosstalk may result in a disrupted host health state, while small-molecule metabolites such as SCFAs, Trp, BAs, etc

Collectively, the pathogenic role of GSH depletion in alcohol-induced liver injury remains to be defined