In both Europe and the United States, the peptide has been approved as afamelanotide to prevent skin damage from sun exposure in patients with erythropoietic protoporphyria, a rare skin condition characterized by acute non-blistering photosensitivity, sunlight intolerance, and a significant reduction in quality of life [6]
Nakajima K, Lee MG, Bin BH, Hara T, Takagishi T, Chae S et al (2020) Possible involvement of zinc transporter ZIP10 in atopic dermatitis
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In addition, myelin structure becomes dysregulated particularly in the white matter, with myelin thickening, outfoldings, unravelling, enlargement of inner tongues 90,91,92