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Some tiredness can be part of the adjustment period on GLP-1 medicines especially after dose changes but you should get medical advice sooner rather than later if symptoms are severe, persistent, or escalating

Furthermore, these substantial results are typically realized over a specific timeframeoften 68 weeksemphasizing that this is a long-term medical journey, and success requires patience, strict adherence, and the close supervision of a medical professional

Metabolic liver disease: Randomized trials in metabolic dysfunctionassociated steatotic liver disease (MASLD/MASH) evaluate its impact on liver fat content, inflammation, and fibrosis markers

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Individual variation in drug response is significantbiological differences in GLP-1 receptor expression and function may contribute to why some patients naturally respond more robustly than others, though this is not routinely assessed in clinical practice