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JAMA 2025;333:113-4

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101 In patients with T2DM and overweight or obesity, 16 weeks of danuglipron administered twice daily at a maximum dose of 120 mg yielded placebo-adjusted weight loss of up to 4.2 kg and a reduction in mean HbA1c levels of up to 1.2% relative to placebo in the highest dose group

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In the current study, the dose range was 23 g/day, there was no significant dose-dependence from l-carnitine efficacy on BMI in T2DM patients, so the lower dose of 2 g/day was selected as recommended dose