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equina adult worms, MCF-7 human breast cancer, and Huh-7 hepatoma cells, possibly corresponding to Glucose-6-phosphate dehydrogenase (G6PD), and HSP-70 respectively [81]

In our experiments, the concentration of CB-839 needed for effective, functional glutaminase inhibition varied from 10 nM to 1 M, and the antiproliferative IC 50 was determined as 0.41 M for the HG-3 cell line and 66.2 M for the MEC-1 cell line

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